01
ARS-native shell design
Design tables, figures, and listings as Analysis Display Metadata aligned to the CDISC Analysis Results Standard.
CLYMBR HUB · TFL SHELLS, ARD & OUTPUTSTFL Designer ™ +
Code Generators
From ARS-driven TFL shells to production-ready SAS and R code in one connected workspace.
TFL Designer + Code Generators combines shell design, mock-up generation, and AI-powered code creation for Tables, Figures, and Listings. Design ARS-aligned shells, auto-populate mock-ups, and generate first-draft SAS and R programs , plus matching QC scripts , from the same metadata so specifications and code never drift apart.
- CDISC Analysis Results Standard (ARS) native
- Mock-up and shell generation with auto-populated results
- AI-generated SAS and R code from approved shells
- Matching QC scripts generated alongside production code
TFL Designer + Code Generators , in the workflow— / 05
upstream
Approved SAP metadata defines the analyses that the shell set must cover.
85%
Faster TFL shell creation
Shell development, review, updates, and approval drop from ~120 hours to ~18 hours per study.
60%
Less output programming & QC
First-draft TFL output development and QC falls from ~16 hours per output to ~6.5 hours per output.
70–80%
Faster code with the AI generator
Production-ready SAS and R code is generated directly from approved, ARS-aligned shells.
Capabilities
What TFL Designer + Code Generators does
Shells become structured metadata, and that metadata drives both the mock-ups your team reviews and the code your programmers run.
02
Mock-up generation
Auto-populate realistic mock-up shells so reviewers see exactly what the final output will look like.
03
AI Code Generator
Generate first-draft, production-ready SAS and R programs directly from approved, ARS-aligned shells.
04
Matching QC scripts
Produce companion QC programs alongside every generated production program for independent verification.
05
Template and standards library
Reuse a growing library of shell templates, including FDA Safety Tables and Figures Integrated Guide (STF-IG) templates.
06
TOC and export
Produce the TFL table of contents and export shells to RTF, PDF, XML, and JSON for any downstream consumer.
07
Versioning and approval
Track shell changes, review with stakeholders, and approve with e-signature before programming begins.
How it works
TFL Designer + Code Generators in the workflow
TFL Designer + Code Generators sits between the approved SAP and the review workspace, turning signed-off shells into executable SAS and R programs.
Inherit from the SAP
Analyses approved in SAP Builder generate the initial shell set with populations and parameters already attached.
Design the displays
Lay out each table, figure, and listing as structured display metadata with titles, footnotes, and formats.
Review and approve shells
Circulate mock-ups, capture comments, version the shells, and sign off before any code is written.
Generate the code
The AI Code Generator produces first-draft SAS and R programs plus matching QC scripts against the approved shells and ADaM data.
Execute and iterate
Run the generated code inside the SCE, review outputs in TFL Viewer, and regenerate automatically when shells or data change.
Free community edition
TFL Designer Community Edition
Explore a free, web-based version of TFL Designer with a growing library of community templates, FDA STF-IG shells, and CDISC ARS standards.
- No login required to browse templates
- FDA Safety Tables and Figures Integrated Guide (STF-IG) shells
- Downloadable ARS-aligned shell metadata
tfldesigner.org
TFL Designer Community Edition
Community templates & standards
FDA STF-IG templates
ARS shells
Mock-up library
Open standards
Key functionalities
Everything included in TFL Designer + Code Generators
A secure, cloud-based module of Clymbr Hub , governed, versioned, and audit-ready from day one.
11 capabilities shipped today
Platform
Secure cloud-based, scalable solution
Runs inside Clymb's validated Statistical Computing Environment with role-based access, encryption in transit and at rest, and elastic compute for large output sets.
Select any capability to see what it does.
Code generators compared
AI Code Generator, siera and atlas
Three ways to turn approved TFL Designer shells into executable code. All three read the same CDISC ARS metadata, so you can mix them across a programme without re-specifying a single output.
AI Code Generator
Agentic AI · inside TFL Designer
AI Code Generator lets users generate their SAS or R code directly within TFL Designer in a matter of seconds, eliminating manual programming and dramatically accelerating output creation and QC workflows.
- SAS and R template code generation in minutes
- Seamless ARS standard integration
- Connectivity to any Statistical Computing Environment (SCE)
- Agentic AI for smarter, scalable TFL workflows
Works in either language
Produces template SAS or R code from the same approved shell, so mixed-language teams stay on one specification.
Standards-aware by design
Reads CDISC ARS metadata from TFL Designer, keeping generated code aligned to the analysis definition.
Runs where you run
Connects to your statistical computing environment so generated programs execute inside your validated setup.
| Attribute | AI Code Generator | siera | atlas |
|---|---|---|---|
| Output language | SAS or R | R | SAS |
| How it works | Agentic AI drafts code from the approved shell | Metadata-driven R scripts and ARDs | Metadata plus macro library into SAS programs |
| Standard | CDISC ARS + sponsor-specific standards | CDISC ARS + sponsor-specific standards | CDISC ARS / ARD + sponsor-specific standards |
| Best for | Probabilistic approach , speed across mixed SAS and R teams | Deterministic approach , open-source R teams and ARD generation | Deterministic approach , established SAS macro environments |
| Availability | Clymbr Hub module | Open source (GitHub, Pharmaverse) | Clymbr Hub Module or SAS |
| Maturity level | Mature | Very Mature | Very Mature |
Standards & compliance
Built to the standards your submission expects
- CDISC ARS
- Analysis Display Metadata (ADM)
- CDISC ADaM
- FDA STF-IG
- RTF / PDF / XML / JSON
- SAS
- R
Who uses it
Teams working in the same workspace
- Statistical programmers
- Biostatisticians
- TFL standards leads
- QC reviewers
- Outsourcing / FSP teams
Common questions
About TFL Designer + Code Generators
What is TFL Designer + Code Generators?+
It is a combined Clymbr Hub module that designs Tables, Figures, and Listings as structured CDISC ARS metadata, then converts those approved shells into first-draft SAS and R programs with matching QC scripts. Shells and code stay in sync because both are generated from the same source of truth.
How does the AI Code Generator work?+
The AI Code Generator reads the approved ARS-aligned shell, ADaM dataset structure, and sponsor macro library to produce production-ready SAS and R programs. It also drafts matching QC scripts, compressing weeks of manual programming into hours while keeping outputs aligned with your CDISC metadata.
Is there a free community version?+
Yes. A free community version of TFL Designer is available at tfldesigner.org with a growing library of templates, use cases, and standards, including templates based on the FDA Safety Tables and Figures Integrated Guide (STF-IG).
Which standards does it support?+
The module is built on CDISC ARS (Analysis Results Standard) and interoperates with SDTM and ADaM. FDA STF-IG templates are included in the community version, and generated code aligns with SAS and R best practices.
See TFL Designer + Code Generators inside Clymbr Hub.
Bring your team, your study, and your code. We'll show you TFL Designer + Code Generators working end-to-end alongside the rest of the platform.